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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: LGUL_HUMAN




USC-OGP 2-DE database:  LGUL_HUMAN


LGUL_HUMAN


General information about the entry
View entry in simple text format
Entry nameLGUL_HUMAN
Primary accession numberQ04760
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Lactoylglutathione lyase; EC=4.4.1.5; AltName: Full=Aldoketomutase; AltName: Full=Glyoxalase I; Short=Glx I; AltName: Full=Ketone-aldehyde mutase; AltName: Full=Methylglyoxalase; AltName: Full=S-D-lactoylglutathione methylglyoxal lyase;.
Gene nameName=GLO1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=4.87; Mw=21103



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.03; Mw=21553



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.03; Mw=21803

Cross-references
UniProtKB/Swiss-ProtQ04760; LGUL_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameLGUL_HUMAN
Primary accession numberQ04760
Secondary accession number(s) B2R6P7 B4DDV0 P78375 Q59EL0 Q5TZW3 Q96FC0 Q96J41
Sequence was last modified on March 6, 2007 (version 4)
Annotations were last modified on March 15, 2017 (version 180)
Name and origin of the protein
DescriptionRecName: Full=Lactoylglutathione lyase; EC=4.4.1.5; AltName: Full=Aldoketomutase; AltName: Full=Glyoxalase I; Short=Glx I; AltName: Full=Ketone-aldehyde mutase; AltName: Full=Methylglyoxalase; AltName: Full=S-D-lactoylglutathione methylglyoxal lyase;
Gene nameName=GLO1
Encoded onName=GLO1
Keywords3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glutathionylation; Lyase; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD13315; BAA02572.1; -; mRNA
EMBLL07837; AAA52565.1; -; mRNA
EMBLS83285; AAB49495.1; -; mRNA
EMBLAF146651; AAD38008.1; -; Genomic_DNA
EMBLAB209801; BAD93038.1; ALT_INIT; mRNA
EMBLAK293345; BAG56861.1; -; mRNA
EMBLAK312662; BAG35544.1; -; mRNA
EMBLBT019987; AAV38790.1; -; mRNA
EMBLBT019988; AAV38791.1; -; mRNA
EMBLAL391415; CAI21586.1; -; Genomic_DNA
EMBLBC001741; AAH01741.1; -; mRNA
EMBLBC011365; AAH11365.1; -; mRNA
EMBLBC015934; AAH15934.1; -; mRNA
CCDSCCDS4837.1; -. [Q04760-1]; .
PIRA46714; A46714; .
PIRS63603; S63603; .
RefSeqNP_006699.2; NM_006708.2. [Q04760-1]; .
UniGeneHs.268849; -; .
PDB1BH5; X-ray; 2.20 A; A/B/C/D=2-184
PDB1FRO; X-ray; 2.20 A; A/B/C/D=2-184
PDB1QIN; X-ray; 2.00 A; A/B=2-184
PDB1QIP; X-ray; 1.72 A; A/B/C/D=2-184
PDB3VW9; X-ray; 1.47 A; A/B=1-184
PDB3W0T; X-ray; 1.35 A; A/B/C/D=1-184
PDB3W0U; X-ray; 1.70 A; A/B=1-184
PDBsum1BH5; -; .
PDBsum1FRO; -; .
PDBsum1QIN; -; .
PDBsum1QIP; -; .
PDBsum3VW9; -; .
PDBsum3W0T; -; .
PDBsum3W0U; -; .
ProteinModelPortalQ04760; -; .
SMRQ04760; -; .
BioGrid109001; 38; .
IntActQ04760; 4; .
STRING9606.ENSP00000362463; -; .
BindingDBQ04760; -; .
ChEMBLCHEMBL2424; -; .
DrugBankDB03345; Beta-Mercaptoethanol; .
DrugBankDB00143; Glutathione; .
DrugBankDB00328; Indomethacin; .
DrugBankDB03330; S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione; .
DrugBankDB03602; S-Benzyl-Glutathione; .
DrugBankDB04132; S-Hexylglutathione; .
DrugBankDB03130; S-P-Nitrobenzyloxycarbonylglutathione; .
iPTMnetQ04760; -; .
PhosphoSitePlusQ04760; -; .
SwissPalmQ04760; -; .
BioMutaGLO1; -; .
DMDM134039205; -; .
OGPQ04760; -; .
REPRODUCTION-2DPAGEIPI00220766; -; .
REPRODUCTION-2DPAGEQ04760; -; .
EPDQ04760; -; .
PaxDbQ04760; -; .
PeptideAtlasQ04760; -; .
PRIDEQ04760; -; .
DNASU2739; -; .
EnsemblENST00000373365; ENSP00000362463; ENSG00000124767. [Q04760-1]; .
GeneID2739; -; .
KEGGhsa:2739; -; .
CTD2739; -; .
DisGeNET2739; -; .
GeneCardsGLO1; -; .
HGNCHGNC:4323; GLO1; .
HPACAB040541; -; .
HPACAB040542; -; .
HPAHPA059791; -; .
MIM138750; gene; .
neXtProtNX_Q04760; -; .
OpenTargetsENSG00000124767; -; .
PharmGKBPA28724; -; .
eggNOGENOG410IU7X; Eukaryota; .
eggNOGENOG4111FDV; LUCA; .
GeneTreeENSGT00390000009312; -; .
HOVERGENHBG025852; -; .
InParanoidQ04760; -; .
KOK01759; -; .
OMAWMKSIPG; -; .
OrthoDBEOG091G0GMY; -; .
PhylomeDBQ04760; -; .
TreeFamTF105011; -; .
BRENDA4.4.1.5; 2681; .
ReactomeR-HSA-70268; Pyruvate metabolism; .
SABIO-RKQ04760; -; .
UniPathwayUPA00619; UER00675; .
ChiTaRSGLO1; human; .
EvolutionaryTraceQ04760; -; .
GeneWikiGLO1; -; .
GeneWikiLactoylglutathione_lyase; -; .
GenomeRNAi2739; -; .
PROPR:Q04760; -; .
ProteomesUP000005640; Chromosome 6; .
BgeeENSG00000124767; -; .
CleanExHS_GLO1; -; .
ExpressionAtlasQ04760; baseline and differential; .
GenevisibleQ04760; HS; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0005829; C:cytosol; IDA:HPA; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:HPA; .
GOGO:0005886; C:plasma membrane; IDA:HPA; .
GOGO:0004462; F:lactoylglutathione lyase activity; IDA:UniProtKB; .
GOGO:0008270; F:zinc ion binding; IDA:UniProtKB; .
GOGO:0005975; P:carbohydrate metabolic process; NAS:ProtInc; .
GOGO:0006749; P:glutathione metabolic process; IEA:Ensembl; .
GOGO:0009438; P:methylglyoxal metabolic process; IEA:Ensembl; .
GOGO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; .
GOGO:0030316; P:osteoclast differentiation; ISS:UniProtKB; .
GOGO:0006090; P:pyruvate metabolic process; TAS:Reactome; .
GOGO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Ensembl; .
Gene3D3.10.180.10; -; 1; .
InterProIPR029068; Glyas_Bleomycin-R_OHBP_Dase; .
InterProIPR004360; Glyas_Fos-R_dOase_dom; .
InterProIPR004361; Glyoxalase_1; .
InterProIPR018146; Glyoxalase_1_CS; .
PfamPF00903; Glyoxalase; 1; .
SUPFAMSSF54593; SSF54593; 1; .
TIGRFAMsTIGR00068; glyox_I; 1; .
PROSITEPS00934; GLYOXALASE_I_1; 1; .
PROSITEPS00935; GLYOXALASE_I_2; 1; .
PROSITEPS51819; VOC; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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